N-methyl-2-toluamide → HCID 22502446, compound

HRID 1006971Notes

Reaction equation

HRID 1006971 reaction equation
[CH3:1][NH:2][C:3](=[O:11])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH3:10].C([C:14]1[CH:19]=[CH:18][C:17]([S:20][CH3:21])=[CH:16][CH:15]=1)#N>>[CH3:21][S:20][C:17]1[CH:18]=[CH:19][C:14]([C:1]2[NH:2][C:3](=[O:11])[C:4]3[C:5]([CH:10]=2)=[CH:6][CH:7]=[CH:8][CH:9]=3)=[CH:15][CH:16]=1

Participants

3

Reactant 2

HCID 75111N-methyl-2-toluamideHCID 5909604-(Methylthio)benzonitrile

Product 1

HCID 22502446HCID 22502446, compoundYield 46.7%

Procedure

According to the method of Example 10-1, N-methyl-2-methylbenzamide (5.97 g) and 4-cyanothioanisole (5.97 g) were reacted, to give 3-(4-methylthiophenyl)isoquinolin-1-one (5.00 g).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-410dc0e08e804564ba15e93c4e35279d
Source dataset
uspto-grants-2004_09
Patent number
US06790844B2

Reaction notes

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