Hydrochloric Acid → HCID 12009735, compound

Participants

Reaction Conditions

Reaction Steps

4.40 g (14.7 mmol) of 2-(1-methyl-3-trifluoromethylpyrazol-5-yloxy)-6-(formylaminomethyl)-pyridine were dissolvej in 45 ml of anhydrous THF under an inert gas atmosphere and at 0° C. 4.17 ml (44.0 mmol) of borane dimethylsulfide complex were added to the solution. The mixture was heated at 50° C. for 2.5 h. After cooling to room temperature, the reaction solution was admixed with 100 ml of 2 N HCl, stirred for 1 h and then extracted with ethyl acetate. The aqueous phase was rendered alkaline with 2 N NaOH and subjected to repeated extraction with ethyl acetate. The extracts were dried over MgSO4 and concentrated to dryness.

Provenance & Evidence