反应详情

7 g of 4-[3-(3-hydroxy-3-phenylpropyl)-2-(4-methoxyphenyl)-4-oxoazetidin-1-yl]-benzonitrile are dissolved in 200 ml of ethanol and, after addition of 15 ml of concentrated ammonia, hydrogenated with 7 g of 50% aqueous Raney nickel under 50 bar of hydrogen. The crude product obtained after removal of the catalyst by filtration with suction and removal of the solvent in vacuo is purified on silica gel with dichloromethane/methanol/ammonia =200:10:1. The amine is obtained. MS (FAB, +LiCI): 423 (M+Li+) [C26H28N2O3 M=416].

1. customThe crude product obtained
2. customafter removal of the catalyst
3. filtrationby filtration
4. customwith suction and removal of the solvent in vacuo
5. customis purified on silica gel with dichloromethane/methanol/ammonia =200:10:1