反应详情

An acetic acid (3 ml) solution of the 4-nitrobenzylpiperidine compound (25) (65.8 mg, 0.2 mmol) obtained in the process 2 was added with zinc (300 mg) little by little at 0° C. After having been stirred at the room temperature for 2 hours, this was filtered to be taken out, had the solvent distilled out and neutralized with 2M aqueous sodium hydroxide, and then was extracted with ethylacetate. The resultant was washed with water and the saturated saline solution, dried and then vacuum concentrated, thus obtained a 4-aminobenzylpiperidine compound (26:R=2,2-dimethylcyclopropane) in the form of a yellow oily matter (50 mg, 85%).

1. filtrationthis was filtered
2. distillationdistilled out
3. extractionwas extracted with ethylacetate
4. washThe resultant was washed with water
5. customthe saturated saline solution, dried
6. concentrationvacuum concentrated