Tert-butyl 4-hydroxy-3-nitrobenzoate → tert-Butyl 3-amino-4-hydroxybenzoate

Participants

Reaction Steps

To a solution of tert-butyl 4-hydroxy-3-nitrobenzoate (4.4 g, 18.4 mmol) in methanol (50 mL), 10% Pd/C (200 mg) was added and the resulting suspension was hydrogenated at 50 psi for 4 hours. After filtering under a pad of celite, methanol was removed in vacuo to obtain the title compound as a greenish powder (3.5 g, 95%).

Provenance & Evidence