Water → HCID 10269103, compound

Participants

Reaction Steps

To a mixture of 6-chloronicotinoyl chloride (100 mg, 0.6 mmol) and 2-nitro-4-trifluoromethylaniline (117 mg, 0.6 mmol) in THF (10 ml) was added triethylamine (0.16 ml, 1.1 mmol). The mixture was stirred at room temperature overnight and then diluted with ethyl acetate. Water was added to dissolve the precipitate and the organic phase was separated and washed with water, then dried over anhydrous sodium sulfate. The product was purified by column chromatography to give the title compound as a pale yellow solid. 1H NMR (DMSO-d6): 11.27 (s, 1H), 8.97 (d, J=2.7, 1H), 8.38-8.35 (m, 2H), 8.19 (d, J=8.4, 1H), 7.96 (d, J=8.7, 1H), 7.78 (d, J=8.1, 1H).

Provenance & Evidence