4-Benzyloxy-2-nitroaniline → HCID 10110525, compound

HRID 1007200Notes

Reaction equation

HRID 1007200 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][N:3]=1.[CH2:11]([O:18][C:19]1[CH:25]=[CH:24][C:22]([NH2:23])=[C:21]([N+:26]([O-:28])=[O:27])[CH:20]=1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>>[Cl:1][C:2]1[N:3]=[CH:4][C:5]([C:6]([NH:23][C:22]2[CH:24]=[CH:25][C:19]([O:18][CH2:11][C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[CH:20][C:21]=2[N+:26]([O-:28])=[O:27])=[O:7])=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 2614974-Benzyloxy-2-nitroanilineHCID 27821656-Chloronicotinoyl Chloride

Product 1

HCID 10110525HCID 10110525, compound

Procedure

The title compound was prepared from 6-chloronicotinoyl chloride and 4-benzyloxy-2-nitroaniline and was obtained as a yellow solid as described in Example 1. 1H NMR (CDCl3): 11.13 (bs, 1H), 9.00 (d, J=3.0, 1H), 8.83 (d, J=9.3, 1H), 8.23-8.20 (m, 1H), 7.85 (d, J=3.0, 1H), 7.53-7.46 (m, 1H), 7.44-7.37 (m, 6H), 5.15 (s, 2H).

Workup

  1. customwas obtained as a yellow solid

Sources & evidence

ORD record
ord-5ac9387351e14ec4a496fb0295056d26
Source dataset
uspto-grants-2004_09
Patent number
US06794397B2

Reaction notes

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