Methyl 2-amino-5-chlorobenzoate → HCID 22668927, compound

HRID 1007211Notes

Reaction equation

HRID 1007211 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][N:3]=1.[NH2:11][C:12]1[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][C:13]=1[C:14]([O:16][CH3:17])=[O:15]>>[Cl:1][C:2]1[N:3]=[CH:4][C:5]([C:6]([NH:11][C:12]2[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][C:13]=2[C:14]([O:16][CH3:17])=[O:15])=[O:7])=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 78878Methyl 2-amino-5-chlorobenzoateHCID 27821656-Chloronicotinoyl Chloride

Product 1

HCID 22668927HCID 22668927, compound

Procedure

The title compound was prepared from 6-chloronicotinoyl chloride and methyl 2-amino-5-chlorobenzoate as a white solid as described in Example 1. 1H NMR (CDCl3): 12.13 (s, 1H), 9.06 (d, J=3.0, 1H), 8.86 (d, J=9.3, 1H), 8.29-8.25 (m, 1H), 8.08 (d, J=2.4, 1H), 7.60-7.57 (m, 1H), 7.50 (d, J=8.4, 1H), 3.99 (s, 3H).

Sources & evidence

ORD record
ord-96272f4526ab4b6ea7cddfaeca4fa780
Source dataset
uspto-grants-2004_09
Patent number
US06794397B2

Reaction notes

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