4-Ethoxy-2-nitroaniline → HCID 9943805, compound

HRID 1007215Notes

Reaction equation

HRID 1007215 reaction equation
[N:1]1[CH:6]=[C:5]([C:7]([OH:9])=O)[CH:4]=[N:3][CH:2]=1.[CH2:10]([O:12][C:13]1[CH:19]=[CH:18][C:16]([NH2:17])=[C:15]([N+:20]([O-:22])=[O:21])[CH:14]=1)[CH3:11]>>[CH2:10]([O:12][C:13]1[CH:19]=[CH:18][C:16]([NH:17][C:7]([C:5]2[CH:4]=[N:3][CH:2]=[N:1][CH:6]=2)=[O:9])=[C:15]([N+:20]([O-:22])=[O:21])[CH:14]=1)[CH3:11]

Participants

3

Reactant 2

HCID 692294-Ethoxy-2-nitroanilineHCID 78346Pyrimidine-5-carboxylic acid

Product 1

HCID 9943805HCID 9943805, compound

Procedure

The title compound was prepared from pyrimidine-5-carboxylic acid and 4-ethoxy-2-nitroaniline as a yellow solid as described in Example 15. 1H NMR (CDCl3): 11.16 (s, 1H), 9.43 (s, 1H), 9.32 (s, 2H), 8.81 (d, J=9.3, 1H), 7.76 (d, J=3.0, 1H), 7.34-7.27 (m, 1H), 4.12 (q, J=6.9, 2H), 1.47 (t, J=6.9, 3H).

Sources & evidence

ORD record
ord-28fee55743aa421cafa08e3c496d7228
Source dataset
uspto-grants-2004_09
Patent number
US06794397B2

Reaction notes

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