5-Amino-4,6-dichloropyrimidine → HCID 22668915, compound

HRID 1007225Notes

Reaction equation

HRID 1007225 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][N:3]=1.[NH2:11][C:12]1[C:13]([Cl:19])=[N:14][CH:15]=[N:16][C:17]=1[Cl:18]>>[Cl:1][C:2]1[N:3]=[CH:4][C:5]([C:6]([NH:11][C:12]2[C:13]([Cl:19])=[N:14][CH:15]=[N:16][C:17]=2[Cl:18])=[O:7])=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 794345-Amino-4,6-dichloropyrimidineHCID 27821656-Chloronicotinoyl Chloride

Product 1

HCID 22668915HCID 22668915, compound

Procedure

The title compound was prepared from 6-chloronicotinoyl chloride and 5-amino-4,6-dichloropyrimidine as a white solid as described in Example 1. 1H NMR (CDCl3): 8.95 (d, J=2.4, 1H), 8.78 (s, 1H), 8.25-8.22 (m, 1H), 7.57 (s, 1H), 7.54 (d, J=8.4, 1H).

Sources & evidence

ORD record
ord-7533afa1941e49458e4a9ef4faecebbe
Source dataset
uspto-grants-2004_09
Patent number
US06794397B2

Reaction notes

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