Hydrochloric Acid → HCID 69023929, compound

Participants

Reaction Steps

A solution of 520 mg of cis-N-tert-butoxycarbonyl-2-[2-(4-chlorostyryl)-6-methoxyquinazolin-4-yl]aminocyclohexylamine in 10 mL of methanol was combined with 5 mL of a 4 N solution of hydrogen chloride in ethyl acetate, and reacted at 50° C. for 24 hours. After the solvent was distilled off, the residue was basified by addition of a 10% aqueous solution of sodium hydroxide, and extracted with chloroform. After concentrating, the residue was purified by column chromatography on silica gel (chloroform:methanol=10:1) to obtain 378 mg of the desirable compound.

Provenance & Evidence