HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 69023628, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | (1S,2R)-Cyclohexane-1,2-diamine, N1-BOC protected | HCID 1514389 | — |
| Reactant | Ethyl 4-chloro-6-methoxyquinazoline-2-carboxylate | HCID 22668047 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 69023628 | HCID 69023628 | 82.6% |
Reaction Steps
A solution of 1.96 g of 4-chloro-2-ethoxycarbonyl-6-methoxyquinazoline in 70 mL of toluene was combined with 1.58 g of cis-2-tert-butoxycarbonylaminocyclohexylamine and 0.74 g of triethylamine, and heated under reflux for 15 hours. After concentrating, the mixture was combined with water, extracted with chloroform, and dried. After the solvent was distilled off, the residue was purified by column chromatography on silica gel (chloroform) to obtain 2.70 g of the desirable compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06794389B2 |
| Source dataset | uspto-grants-2004_09 |
| ORD ID | ord-37b4df8e77f64723928f29fa98dbbe9e |
| Source note | uspto-grants-2004_09 |