Sodium Hydroxide → HCID 69023783, compound

HRID 1007298Notes

Reaction equation

HRID 1007298 reaction equation
[C:1]([O:5][C:6]([NH:8][C@@H:9]1[CH2:14][CH2:13][CH2:12][CH2:11][C@@H:10]1[NH:15][C:16]1[C:25]2[C:20](=[CH:21][CH:22]=[C:23]([O:26][CH3:27])[CH:24]=2)[N:19]=[C:18]([C:28]([O:30]CC)=[O:29])[N:17]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[OH-].[Na+].S([O-])(O)(=O)=O.[K+]>CO>[C:1]([O:5][C:6]([NH:8][C@@H:9]1[CH2:14][CH2:13][CH2:12][CH2:11][C@@H:10]1[NH:15][C:16]1[C:25]2[C:20](=[CH:21][CH:22]=[C:23]([O:26][CH3:27])[CH:24]=2)[N:19]=[C:18]([C:28]([OH:30])=[O:29])[N:17]=1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 516920Potassium bisulfateHCID 69023628HCID 69023628, compound

Product 1

HCID 69023783HCID 69023783, compoundYield 69.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 1.70 g of cis-N-tert-butoxycarbonyl-2-(2-ethoxycarbonyl-6-methoxyquinazolin-4-yl)aminocyclohexylamine in 5 mL of methanol was combined with 5 mL of a 1N aqueous solution of sodium hydroxide, and stirred at room temperature for 3 hours. After the pH was adjusted to 5 by addition of a 1N aqueous solution of potassium hydrogen sulfate to the reaction solution, which was then extracted with chloroform and dried. After the solvent was distilled off, the residue was purified by column chromatography on silica gel (chloroform:methanol=10:1) to obtain 1.10 g of the desirable compound.

Workup

  1. extractionwas then extracted with chloroform
  2. customdried
  3. distillationAfter the solvent was distilled off
  4. customthe residue was purified by column chromatography on silica gel (chloroform:methanol=10:1)

Sources & evidence

ORD record
ord-ed171331775b4488b2565c4fa6c23950
Source dataset
uspto-grants-2004_09
Patent number
US06794389B2

Reaction notes

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