Potassium Hydroxide → HCID 69022112, compound

Participants

Reaction Steps

A solution of 300 mg of cis-N-tert-butoxycarbonyl-2-(2-ethoxycarbonylamino-6-methoxyquinazolin-4-yl)aminocyclohexylamine in 10 mL of methanol was combined with a 50 mg of potassium hydroxide powder, and stirred at room temperature for 3 hours. The reaction solution was neutralized by addition of a saturated aqueous solution of ammonium chloride, and then extracted with chloroform and dried. After the solvent was distilled off, the residue was purified by column chromatography on silica gel (chloroform:methanol=10:1) to obtain 250 mg of the desirable compound.

Provenance & Evidence