Water → HCID 69020964, compound

Participants

Reaction Steps

A solution of 68 mg of 4-chlorobenzoyl chloride and 200 mg of diisopropylethylamine in 8 mL of methylene chloride was combined with 150 mg of cis-2-(2-amino-6-methoxyquinazolin-4-yl)amino-N-tert-butoxycarbonylcyclohexylamine, and stirred at room temperature for 15 hours. The reaction solution was combined with water, extracted with chloroform, and dried. After the solvent was distilled off, the residue was purified by column chromatography on silica gel (chloroform:methanol=30:1) to obtain 120 mg of the desirable compound.

Provenance & Evidence