Trifluoroacetic acid → HCID 69022848, compound

Participants

Reaction Steps

A solution of 120 mg of cis-N-tert-butoxycarbonyl-2-[2-(4-chlorobenzoylamino)-6-methoxyquinazolin-4-yl]aminocyclohexylamine in 5 mL of methylene chloride was combined with 2 mL of trifluoroacetic acid, and reacted at room temperature for 1 hour. The reaction solution was basified by addition of a saturated solution of sodium hydrogen carbonate, extracted with chloroform, and dried. After the solvent was distilled off, the residue was purified by column chromatography on silica gel (chloroform:methanol=30:1) to obtain 80 mg of the desirable compound.

Provenance & Evidence