Water → HCID 178488017, compound

Participants

Reaction Steps

A solution of 1.76 g of (1R,2S)-N-[N,N′-bis(tert-butoxycarbonyl)]amidino-2-[2-(4-methoxybenzylamino)-6-methoxyquinazolin-4-yl]aminocyclohexylamine in 80 mL of methylene chloride was combined with 3.17 g of N-methylmorpholine-N-oxide and 95 mg of tetrapropylammonium perruthenate, and stirred for 9 hours. The reaction solution was combined with water, extracted with methylene chloride, and dried. After the solvent was distilled off, the residue was purified by column chromatography on silica gel (chloroform:methanol 10:1) to obtain 0.95 g of the desirable compound.

Provenance & Evidence