4-Methoxy-3-(trifluoromethyl)benzoyl chloride → 2-Bromo-4-methoxy-6-{[4-methoxy-3-(trifluoromethyl)benzoyl]amino}phenyl 4-methoxy-3-(trifluoromethyl)benzoate

HRID 1007363Notes

Reaction equation

HRID 1007363 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[C:4]([Br:10])[C:3]=1[OH:11].[CH3:12][O:13][C:14]1[CH:22]=[CH:21][C:17]([C:18](Cl)=[O:19])=[CH:16][C:15]=1[C:23]([F:26])([F:25])[F:24]>>[CH3:12][O:13][C:14]1[CH:22]=[CH:21][C:17]([C:18]([O:11][C:3]2[C:2]([NH:1][C:18](=[O:19])[C:17]3[CH:21]=[CH:22][C:14]([O:13][CH3:12])=[C:15]([C:23]([F:26])([F:24])[F:25])[CH:16]=3)=[CH:7][C:6]([O:8][CH3:9])=[CH:5][C:4]=2[Br:10])=[O:19])=[CH:16][C:15]=1[C:23]([F:26])([F:25])[F:24]

Participants

3

Reactant 2

HCID 27752984-Methoxy-3-(trifluoromethyl)benzoyl chlorideHCID 111719822-Amino-6-Bromo-4-Methoxyphenol

Product 1

HCID 226691622-Bromo-4-methoxy-6-{[4-methoxy-3-(trifluoromethyl)benzoyl]amino}phenyl 4-methoxy-3-(trifluoromethyl)benzoate

Procedure

The title compound was prepared in substantially the same manner as described in Example 20, Step c, from 2-amino-6-bromo-4-methoxyphenol and 4-methoxy-3-trifluoromethyl benzoyl chloride. The product was obtained as an off-white solid, m.p. 205-208° C.; MS m/e 622 (M+H)+.

Workup

  1. customThe product was obtained as an off-white solid, m.p. 205-208° C.

Sources & evidence

ORD record
ord-39ead6128a0840c88b69561536df3684
Source dataset
uspto-grants-2004_09
Patent number
US06794403B2

Reaction notes

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