4-Methoxy-2-methylbenzoic acid → 7-Bromo-2-(4-hydroxy-2-methylphenyl)benzo[d]oxazol-5-ol

HRID 1007369Notes

Reaction equation

HRID 1007369 reaction equation
C[O:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=O)=[C:5]([CH3:12])[CH:4]=1.[NH2:13][C:14]1[CH:19]=[C:18]([O:20]C)[CH:17]=[C:16]([Br:22])[C:15]=1O>>[Br:22][C:16]1[C:15]2[O:9][C:7]([C:6]3[CH:10]=[CH:11][C:3]([OH:2])=[CH:4][C:5]=3[CH3:12])=[N:13][C:14]=2[CH:19]=[C:18]([OH:20])[CH:17]=1

Participants

3

Reactant 2

HCID 5972164-Methoxy-2-methylbenzoic acidHCID 111719822-Amino-6-Bromo-4-Methoxyphenol

Product 1

HCID 1354836407-Bromo-2-(4-hydroxy-2-methylphenyl)benzo[d]oxazol-5-ol

Procedure

The title compound was prepared in substantially the same manner as described in Example 21, from 4-methoxy-2-methylbenzoic acid, and 2-amino-6-bromo-4-methoxyphenol, and was obtained as a light purple solid, m.p. 120-135° C.; MS m/e 320 (M+H)+.

Workup

  1. customwas obtained as a light purple solid, m.p. 120-135° C.

Sources & evidence

ORD record
ord-c8ac0ecb27404cbca62b14159bc5718a
Source dataset
uspto-grants-2004_09
Patent number
US06794403B2

Reaction notes

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