Nitric Acid → 4,5-Diethoxy-2-nitro-phenylacetic acid

HRID 1007373Notes

Reaction equation

HRID 1007373 reaction equation
[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([CH2:13][C:14]([OH:16])=[O:15])[CH:7]=[CH:8][C:9]=1[O:10][CH2:11][CH3:12])[CH3:2].[N+:17]([O-])([OH:19])=[O:18]>C(O)(=O)C>[CH2:11]([O:10][C:9]1[C:4]([O:3][CH2:1][CH3:2])=[CH:5][C:6]([CH2:13][C:14]([OH:16])=[O:15])=[C:7]([N+:17]([O-:19])=[O:18])[CH:8]=1)[CH3:12]

Participants

4

Reactant 2

HCID 944Nitric AcidHCID 5798133,4-Diethoxyphenylacetic acid

Product 1

HCID 47122074,5-Diethoxy-2-nitro-phenylacetic acid

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
40 °C

Procedure

0.5 g of 3,4-diethoxy-phenylacetic acid are placed in 10 ml of acetic acid p.a. and 0.5 ml of 659 nitric acid are added dropwise, so that the internal temperature does not rise above 15° C. The mixture is then heated to 40° C. for 0.5 hours. After this time the solution is poured onto ice water and the precipitate formed is suction filtered. The product is washed with water and dried at 100° C.

Workup

  1. customdoes not rise above 15° C
  2. additionAfter this time the solution is poured onto ice water
  3. customthe precipitate formed
  4. filtrationfiltered
  5. washThe product is washed with water
  6. customdried at 100° C.

Sources & evidence

ORD record
ord-825ba08f992944b482b8b0ed44786f9f
Source dataset
uspto-grants-2004_09
Patent number
US06794395B1

Reaction notes

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