Acetic Acid → HCID 178498142, compound

HRID 1007456Notes

Reaction equation

HRID 1007456 reaction equation
[NH2:1][C:2]1[CH:10]=[C:9]2[C:5](/[C:6](=[C:12](/[NH:19][C:20]3[CH:25]=[CH:24][C:23]([C:26]([O:28][CH3:29])=[O:27])=[CH:22][CH:21]=3)\[C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)/[C:7](=[O:11])[NH:8]2)=[CH:4][CH:3]=1.[O-:30][C:31]#[N:32].[K+].C(O)(=O)C>C(O)C>[CH3:29][O:28][C:26]([C:23]1[CH:22]=[CH:21][C:20]([NH:19]/[C:12](=[C:6]2\[C:7](=[O:11])[NH:8][C:9]3[C:5]\2=[CH:4][CH:3]=[C:2]([NH:1][C:31]([NH2:32])=[O:30])[CH:10]=3)/[C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)=[CH:25][CH:24]=1)=[O:27]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 11378442Potassium cyanateHCID 178498140HCID 178498140, compound

Product 1

HCID 178498142HCID 178498142, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

560 mg of 6-amino-3-(Z)-[1-(4-methoxycarbonyl-anilino)-1-phenyl-methylidene]-2-indolinone, 236 mg of potassium cyanate and 3.8 ml of glacial acetic acid are dissolved in 20 ml of ethanol and refluxed for 1 hour. After this time the solvent is evaporated, the residue is taken up in methylene chloride, washed with water and dried over sodium sulphate. After evaporation, the product is dried in the desiccator.

Workup

  1. temperaturerefluxed for 1 hour
  2. customAfter this time the solvent is evaporated
  3. washwashed with water
  4. dry with materialdried over sodium sulphate
  5. customAfter evaporation
  6. customthe product is dried in the desiccator

Sources & evidence

ORD record
ord-73260165e18d4d18b75056c883e3a649
Source dataset
uspto-grants-2004_09
Patent number
US06794395B1

Reaction notes

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