HCID 22669595, compound → HCID 22669559, compound

Participants

Reaction Steps

500 mg of 5-(2-chloro-6-methyl-4-nitrophenoxy)-3-isopropyl-1H-indole (Example II) are suspended in 10 ml of ethanol and hydrogenated with 50 mg of palladium on active carbon (10%) at atmospheric pressure for 2 hours. The mixture is filtered through kieselguhr, the solvent is removed in vacuo and the product is purified by chromatography (cyclohexane/ethyl acetate). 271 mg of 3-chloro-4-[(3-isopropyl-1H-indol-5-yl)oxy]-5-methylaniline are obtained.

Provenance & Evidence