反应详情

1.273 g (3.02 mmol) of triphenylphosphine dibromide are added under argon in portions at 0° C. to a solution of 0.97 g (2.32 mmol) of benzyl alcohol derivative from Example VI in 15 ml of acetonitrile and 0.3 ml (3.72 mmol) of pyridine. After 15 minutes the cooling bath is removed and the mixture is stirred for 2 hours at room temperature. The reaction solution is concentrated in vacuo, and the residue is dissolved in a little toluene and purified by chromatography on silica gel 60 by means of toluene.

1. customAfter 15 minutes the cooling bath is removed
2. concentrationThe reaction solution is concentrated in vacuo
3. dissolutionthe residue is dissolved in a little toluene
4. custompurified by chromatography on silica gel 60 by means of toluene