Sodium borohydride → 4-(3-Isopropyl-1H-indol-5-yloxy)-3,5-dichlorobenzyl alcohol

HRID 1007487Notes

Reaction equation

[CH:1]([C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([O:13][C:14]3[C:21]([Cl:22])=[CH:20][C:17]([CH:18]=[O:19])=[CH:16][C:15]=3[Cl:23])[CH:11]=2)[NH:6][CH:5]=1)([CH3:3])[CH3:2].[BH4-].[Na+]>>[CH:1]([C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([O:13][C:14]3[C:15]([Cl:23])=[CH:16][C:17]([CH2:18][OH:19])=[CH:20][C:21]=3[Cl:22])[CH:11]=2)[NH:6][CH:5]=1)([CH3:3])[CH3:2]

Participants

Reactant 2

HCID 4311764Sodium borohydride

HCID 226696114-(3-Isopropyl-1H-indol-5-yloxy)-3,5-dichloro-benzaldehyde

Product 1

HCID 601106934-(3-Isopropyl-1H-indol-5-yloxy)-3,5-dichlorobenzyl alcohol

Procedure

Preparation is carried out in analogy to the procedure of Example VI from 5.0 g (12.2 mmol) of aldehyde derivative from Example XVI by means of 1.39 g (36.61 mmol) of sodium borohydride.

Workup

customPreparation

Sources & evidence

ORD record: ord-37e051f3df4140799eeadad869dd1707
Source dataset: uspto-grants-2004_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06794406B2

Reaction notes

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