HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → 4-(3-Isopropyl-1H-indol-5-yloxy)-3,5-dichlorophenylacetonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Sodium Cyanide | HCID 8929 | — |
| Reactant | 4-(3-Isopropyl-1H-indol-5-yloxy)-3,5-dichlorobenzyl bromide | HCID 22669624 | — |
| Solvent | N,N-Dimethylformamide--water (1/1) | HCID 21962138 | — |
| Product | 4-(3-Isopropyl-1H-indol-5-yloxy)-3,5-dichlorophenylacetonitrile | HCID 22669850 | — |
Reaction Steps
Analogously to the procedure of Example VIII, 1.0 g (2.42 mmol) of benzyl bromide from Example XVIII is reacted with 0.15 g (3.03 mmol) of sodium cyanide in DMF/H2O (10:1) at 50° C. in 60 min. After isolation of the crude product (distilling off DMF and quenching with ethyl acetate/water), chromatography is carried out on silica gel 60 by means of toluene.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06794406B2 |
| Source dataset | uspto-grants-2004_09 |
| ORD ID | ord-a93689e779454e00ad3b8288f53b9425 |
| Source note | uspto-grants-2004_09 |