Sodium borohydride → 4-(3-Cyclohexylmethyl-1H-indol-5-yloxy)-3,5-bis-trifluoromethyl-benzyl alcohol

HRID 1007491Notes

Reaction equation

HRID 1007491 reaction equation
[CH:1]1([CH2:7][C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([O:17][C:18]4[C:25]([C:26]([F:29])([F:28])[F:27])=[CH:24][C:21]([CH:22]=[O:23])=[CH:20][C:19]=4[C:30]([F:33])([F:32])[F:31])[CH:15]=3)[NH:10][CH:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[BH4-].[Na+]>>[CH:1]1([CH2:7][C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([O:17][C:18]4[C:19]([C:30]([F:31])([F:32])[F:33])=[CH:20][C:21]([CH2:22][OH:23])=[CH:24][C:25]=4[C:26]([F:29])([F:27])[F:28])[CH:15]=3)[NH:10][CH:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 4311764Sodium borohydrideHCID 226699334-(3-Cyclohexylmethyl-1H-indol-5-yloxy)-3,5-bis-trifluoromethyl-benzaldehyde

Product 1

HCID 590609614-(3-Cyclohexylmethyl-1H-indol-5-yloxy)-3,5-bis-trifluoromethyl-benzyl alcohol

Procedure

Preparation is carried out in analogy to the procedure of Example VI from 2.20 g (4.29 mmol) of aldehyde derivative from Example XX with 0.49 g (12.86 mmol) of sodium borohydride.

Workup

  1. customPreparation

Sources & evidence

ORD record
ord-e089913eb3604ea098c91f9f687e4df1
Source dataset
uspto-grants-2004_09
Patent number
US06794406B2

Reaction notes

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