Sodium Hydroxide → HCID 10271133, compound

HRID 1007494Notes

Reaction equation

HRID 1007494 reaction equation
[CH:1]([C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([O:13][C:14]3[C:19]([CH3:20])=[CH:18][C:17]([NH:21][C:22](=[O:28])[CH2:23][C:24]([O:26]C)=[O:25])=[CH:16][C:15]=3[CH3:29])[CH:11]=2)[NH:6][CH:5]=1)([CH3:3])[CH3:2].[OH-].[Na+]>C(O)C>[CH:1]([C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([O:13][C:14]3[C:19]([CH3:20])=[CH:18][C:17]([NH:21][C:22](=[O:28])[CH2:23][C:24]([OH:26])=[O:25])=[CH:16][C:15]=3[CH3:29])[CH:11]=2)[NH:6][CH:5]=1)([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 10200661HCID 10200661, compound

Product 1

HCID 10271133HCID 10271133, compoundYield 47.7%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

50 mg of methyl 3-({4-[(3-isopropyl-1H-indol-5-yl)oxy]-3,5-dimethyl-phenyl}-amino)-3-oxo-propanoate (Example 1) are stirred in 2 ml of ethanol with 30 mg of sodium hydroxide for 30 minutes. The solvent is removed in vacuo. The mixture is taken up in ether/water, the organic phase is dried and the solvent is removed in vacuo. 23 mg (46%) of 3-({4-[(3-isopropyl-1H-indol-5-yl)oxy]-3,5-dimethylphenyl}amino)-3-oxopropanoic acid are obtained.

Workup

  1. customThe solvent is removed in vacuo
  2. customthe organic phase is dried
  3. customthe solvent is removed in vacuo

Sources & evidence

ORD record
ord-3f65712add8e4fec93d835d664f2a99b
Source dataset
uspto-grants-2004_09
Patent number
US06794406B2

Reaction notes

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