HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → Ethyl N-{4-[(3-isopropyl-1H-indol-5-yl)oxy]-3,5-dimethylphenyl}glycinate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Ethyl bromoacetate | HCID 7748 | — |
| Reactant | Sodium Acetate | HCID 517045 | — |
| Reactant | 4-[(3-isopropyl-1H-indol-5-yl)oxy]-3,5-dimethylaniline | HCID 22669700 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Ethyl N-{4-[(3-isopropyl-1H-indol-5-yl)oxy]-3,5-dimethylphenyl}glycinate | HCID 22669446 | — |
Reaction Steps
210 mg of 4-[(3-isopropyl-1H-indol-5-yl)oxy]-3,5-dimethylaniline (Example XV) are brought under reflux with 119 mg of ethyl bromoacetate and 117 mg of sodium acetate in 10 ml of ethanol for 24 h. After addition of water, the mixture is extracted with ether, and the organic phase is dried and concentrated in a rotary evaporator. By chromatographic purification (cyclohexane/ethyl acetate), 143 mg (53%) of ethyl N-{4-[(3-isopropyl-1H-indol-5-yl)oxy]-3,5-dimethylphenyl} glycinate are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06794406B2 |
| Source dataset | uspto-grants-2004_09 |
| ORD ID | ord-8cb5f2a0cd964e3eabd9bd27f4153850 |
| Source note | uspto-grants-2004_09 |