反应详情

Coupling of ketone 5 and 3-(3,4-difluorophenyl)-1-propylamine, using the method given in Example 1, gave 6-(trans-4-[3-(3,4-difluorophenyl)-propylamino]cyclohexyl}-3H-benzoxazol-2-one (690 mg, 37%): 1H NMR (500 MHz, DMSO-d6): δ 7.33-7.24 (m, 2H), 7.12 (d, J=1 Hz, 1H), 7.06-7.02 (m, 1H), 6.98-6.93 (m, 2H), 3.51-3.10 (br s, 2H), 2.62 (dd, J=8, 8 Hz, 2H), 2.55 (dd, J=7, 7 Hz, 2H), 2.48-2.38 (m, 2H), 1.98-1.91 (m, 2H), 1.80-1.73 (m, 2H), 1.71-1.65 (m, 2H), 1.44 (dddd, J=10, 10, 10, 3 Hz, 2H), 1.13 (dddd, J=10, 10, 10, 3 Hz, 2H).