Hydrochloric Acid → HCID 178518608, compound

Participants

Reaction Steps

Coupling of ketone 5 and 3-(2-fluorophenyl)-1-propylamine, using the method given in Example 1, gave 6-{trans-4-[3-(2-fluorophenyl)propylamino]-cyclohexyl}-3H-benzoxazol-2-one (1.7 g, 45%) as the HCl salt: 1H NMR (500 MHz, DMSO-d6): δ 11.50 (s, 1H), 8.86 (s, 2H), 7.34 (t, J=8 Hz, 1H), 7.35-7.26 (m, 1H), 7.19-7.15 (m, 3H), 7.02-6.97 (m, 2H), 3.10-3.03 (m, 1H), 2.98-2.92 (m, 2H), 2.72 (dd, J=8, 8 Hz, 2H), 2.57-2.50 (m, 1H), 2.18-2.13 (m, 2H), 1.98-1.92 (m, 2H), 1.89-1.85 (m, 2H), 1.57-1.46 (m, 4H).

Provenance & Evidence