HuagongsheHuagongshe Chemistry Print Report · For research reference only
(Formyloxy)acetonitrile → (s)-n-Formyl-beta-cyclopropylalanine tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (Formyloxy)acetonitrile | HCID 4205685 | — |
| Reactant | (S)-tert-Butyl 2-amino-3-cyclopropylpropanoate | HCID 12018345 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (s)-n-Formyl-beta-cyclopropylalanine tert-butyl ester | HCID 12018346 | — |
Reaction Steps
A mixture of 10 g (54 mmol) of (S)-β-cyclopropylalanine tert-butyl ester and 4.7 g (55.2 mmol) of cyanomethyl formate in 100 mL of dichloromethane was stirred at room temperature overnight. The residue obtained after removal of the solvent in vacuo was distilled in vacuo. Yield: 8.8 g (76%). Boiling point 120° C./40 Pa (0.3 torr).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06794517B2 |
| Source dataset | uspto-grants-2004_09 |
| ORD ID | ord-fa7a2359d00246fbaccb855bb320c870 |
| Source note | uspto-grants-2004_09 |