HRID1007702

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：O=C(O)c1ccc2c(c1)nc(-c1ccoc1)n2C1CCCCC1

HCID491113

1-Cyclohexyl-2-(furan-3-yl)-1H-benzimidazole-5-carboxylic acid

C18H18N2O3

结构：NC(=O)[C@@H](N)Cc1c[nH]c2ccc([N+](=O)[O-])cc12

HCID59909927

未命名化合物

PRODUCTS

生成物

结构：NC(=O)[C@H](Cc1c[nH]c2ccc(N)cc12)NC(=O)c1ccc2c(c1)nc(-c1ccoc1)n2C1CCCCC1

HCID491183

未命名化合物

PROCEDURE

实验过程

The 5-nitrotryptophan amide derivative of example 53 was coupled to the carboxylic acid of example 2 in the usual manner. The nitro group was then reduced to the corresponding amine using SnCl2 dihydrate as described in example 48, to give the title compound of example 54 after purification by preparative C18 reversed-phase HPLC.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-180cba272b3d4da49535c913c3b87d5d
来源数据集: uspto-grants-2004_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06794404B2
来源说明: uspto-grants-2004_09

反应 SMILES

[N+:1]([C:4]1[CH:18]=[C:17]2[C:7]([NH:8][CH:9]=[C:10]2[CH2:11][C@@H:12]([C:14]([NH2:16])=[O:15])[NH2:13])=[CH:6][CH:5]=1)([O-])=O.[CH:19]1([N:25]2[C:29]3[CH:30]=[CH:31][C:32]([C:34](O)=[O:35])=[CH:33][C:28]=3[N:27]=[C:26]2[C:37]2[CH:41]=[CH:40][O:39][CH:38]=2)[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1>>[NH2:1][C:4]1[CH:18]=[C:17]2[C:7](=[CH:6][CH:5]=1)[NH:8][CH:9]=[C:10]2[CH2:11][C@H:12]([NH:13][C:34]([C:32]1[CH:31]=[CH:30][C:29]2[N:25]([CH:19]3[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]3)[C:26]([C:37]3[CH:41]=[CH:40][O:39][CH:38]=3)=[N:27][C:28]=2[CH:33]=1)=[O:35])[C:14](=[O:15])[NH2:16]