HRID1007714

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：O=C(O)c1ccc2c(c1)nc(-c1ccoc1)n2C1CCCCC1

HCID491113

1-Cyclohexyl-2-(furan-3-yl)-1H-benzimidazole-5-carboxylic acid

C18H18N2O3

结构：COC(=O)c1ccc(C[C@H](N)C(=O)OC)cc1F.Cl

HCID69320128

未命名化合物

PRODUCTS

生成物

结构：O=C(NC(Cc1ccc(C(=O)O)c(F)c1)C(=O)O)c1ccc2c(c1)nc(-c1ccoc1)n2C1CCCCC1

HCID490785

未命名化合物

PROCEDURE

实验过程

Racemic 3-fluoro-4-(carbomethoxy)phenylalanine methyl ester hydrochloride (example 119) was coupled to the carboxylic acid of example 2 in the usual manner and saponified to give the title compound of example 120.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-6382164bb6a143d3a48b46e4a61a3247
来源数据集: uspto-grants-2004_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06794404B2
来源说明: uspto-grants-2004_09

反应 SMILES

Cl.C[O:3][C:4](=[O:19])[C@H:5]([CH2:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]([O:16]C)=[O:15])=[C:10]([F:18])[CH:9]=1)[NH2:6].[CH:20]1([N:26]2[C:30]3[CH:31]=[CH:32][C:33]([C:35](O)=[O:36])=[CH:34][C:29]=3[N:28]=[C:27]2[C:38]2[CH:42]=[CH:41][O:40][CH:39]=2)[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]1>>[C:4]([CH:5]([NH:6][C:35]([C:33]1[CH:32]=[CH:31][C:30]2[N:26]([CH:20]3[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]3)[C:27]([C:38]3[CH:42]=[CH:41][O:40][CH:39]=3)=[N:28][C:29]=2[CH:34]=1)=[O:36])[CH2:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]([OH:16])=[O:15])=[C:10]([F:18])[CH:9]=1)([OH:3])=[O:19]