1-Cyclohexyl-2-(furan-3-yl)-1H-benzimidazole-5-carboxylic acid → HCID 491259, compound

HRID 1007717Notes

Reaction equation

HRID 1007717 reaction equation
Cl.C[O:3][C:4](=[O:18])[C@H:5]([CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([O:16]C)=[O:15])[CH:9]=1)[NH2:6].[CH:19]1([N:25]2[C:29]3[CH:30]=[CH:31][C:32]([C:34](O)=[O:35])=[CH:33][C:28]=3[N:27]=[C:26]2[C:37]2[CH:41]=[CH:40][O:39][CH:38]=2)[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1>>[C:4]([CH:5]([NH:6][C:34]([C:32]1[CH:31]=[CH:30][C:29]2[N:25]([CH:19]3[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]3)[C:26]([C:37]3[CH:41]=[CH:40][O:39][CH:38]=3)=[N:27][C:28]=2[CH:33]=1)=[O:35])[CH2:7][C:8]1[CH:9]=[C:10]([CH:11]=[CH:12][CH:13]=1)[C:14]([OH:16])=[O:15])([OH:3])=[O:18]

Participants

3

Reactant 2

HCID 4911131-Cyclohexyl-2-(furan-3-yl)-1H-benzimidazole-5-carboxylic acidHCID 69315585HCID 69315585, compound

Product 1

HCID 491259HCID 491259, compound

Procedure

Racemic 3-(carbomethoxy)phenylalanine methyl ester hydrochloride (example 119) was coupled to the carboxylic acid of example 2 in the usual manner and saponified to give the title compound of example 1234.

Sources & evidence

ORD record
ord-633a5b4f616a4176b5c5041685201d89
Source dataset
uspto-grants-2004_09
Patent number
US06794404B2

Reaction notes

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