Nitric Acid → 4-Bromomethyl-3-nitrobenzoic acid

Participants

Reaction Conditions

Reaction Steps

α-Bromo-p-toluic acid (21.5 g, 100 mmol) was added in five equal portions to 90% HNO3 (250 mL) at −10° C. The reaction mixtures were stirred at −10° C. for 3 h and poured into ice-water. After stirring at room temperature for 3 h, the white precipitate was filtered, collected and dried by air overnight to give ortho-nitro α-bromo-p-toluic acid (22.2 g, 85%) as slightly yellow solid.

Provenance & Evidence