HuagongsheHuagongshe Chemistry Print Report · For research reference only
Carbon Dioxide → 3,5-Dichloropyrazine-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Carbon Dioxide | HCID 280 | — |
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 2,2,6,6-Tetramethylpiperidine | HCID 13035 | — |
| Reactant | 2,6-Dichloropyrazine | HCID 78504 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3,5-Dichloropyrazine-2-carboxylic acid | HCID 22665536 | — |
Reaction Steps
To a THF solution of 2,2,6,6-tetramethylpiperidine was added n-butyllithium under ice cooling and was further added a THF solution of 2,6-dichloropyrazine at −78° C. After 30 minutes of stirring, dry ice was added to the reaction mixture and, after 30 minutes of stirring, 1 M hydrochloric acid was added thereto. Thereafter, purification in the usual way afforded 3,5-dichloropyrazine-2-carboxylic acid (pale yellow solid). FAB-MS: 191 (M−H)−.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06797706B1 |
| Source dataset | uspto-grants-2004_09 |
| ORD ID | ord-ef85a469255e4bf281f669530eb456b0 |
| Source note | uspto-grants-2004_09 |