Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Chlorophenol | HCID 7245 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | HCID 86759532 | HCID 86759532 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 69686264 | HCID 69686264 | — |
Reaction Steps
o-Chlorophenol and 60% sodium hydride were added to a mixture of 2-[cis-2-(tert-butoxycarbonylamino)cyclohexylamino]-4-chloro-6-(3-methylanilino)pyrimidine-5-carbonitrile and DMF, followed by stirring at room temperature for 30 minutes and at 70° C. for 5 hours. Thereafter, purification in the usual way afforded 2-[cis-2-(tert-butoxycarbonylamino)cyclohexylamino]-4-(2-chlorophenoxy)-6-(3-methylanilino)pyrimidine-5-carbonitrile (colorless solid).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06797706B1 |
|---|
| Source dataset | uspto-grants-2004_09 |
|---|
| ORD ID | ord-0de386c47de44b708e73ab88b9d5daa1 |
|---|
| Source note | uspto-grants-2004_09 |
|---|
