Benzyl Alcohol → HCID 131724598, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of benzyl alcohol and DMF was added 60% sodium hydride under ice cooling and then 2-[cis-2-(tert-butoxycarbonylamino)cyclohexylamino]-6-chloro-4-(3-methylanilino)pyrimidine-5-carbonitrile was added thereto, followed by stirring at 60° C. for 40 minutes. Then, distilled water was added to the reaction liquid and the resulting precipitate was collected by filtration. The filtration product was treated in a similar manner to Reference Example 4 to obtain 2-(cis-2-aminocyclohexylamino)-4-benzyloxy-6-(3-methylanilino)pyrimidine-5-carboxyamide (colorless solid).

Provenance & Evidence