Hydrochloric Acid → 5,5-Diphenylpenta-2,4-dienoic acid

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Reaction Steps

Ethyl 5,5-diphenylpenta-2,4-dienoate (3.70 g) was dissolved in ethanol (68 mL), and 1N sodium hydroxide solution (22 mL) was added thereto, followed by stirring at room temperature for 28.5 hours. Subsequently, while the mixture was stirred under ice-cooling, 1N hydrochloric acid was added thereto, and pH of the resultant mixture was adjusted to about 2. The mixture was condensed to a certain volume under reduced pressure. Water was added to the condensed product, and the thus-obtained solid was collected through filtration and washed several times with water, followed by air-drying, to thereby yield 3.16 g of the product of interest (yield 94.9%).

Provenance & Evidence