Butyl isocyanate → N-[4-(4-amino-2-butyl-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)butyl]-N'-butylurea

Participants

Role	Name	HCID	Charge
Reactant	Butyl isocyanate	HCID 8110	—
Reactant	4-(4-amino-2-butyl 1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)butaneamine	HCID 12992616	—
Product	N-[4-(4-amino-2-butyl-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)butyl]-N'-butylurea	HCID 10001667	65.8%

Reaction Steps

Using the general method of Example 47, butyl isocyanate (54 PL, 0.48 mmol) was reacted with 4-(4-amino-2-butyl-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)butaneamine (0.15 g, 0.48 mmole) to provide 0.13 g of N-[4-(4-amino-2-butyl-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)butyl]-N′-butylurea as a white solid. Analysis: Calculated for C22H33N7O: %C, 64.21; %H, 8.08; %N, 23.82; Found: %C, 64.05; %H, 7.97; %N, 24.00.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06797716B2
Source dataset	uspto-grants-2004_09
ORD ID	ord-a2645bf1e6634dc59aff49adc0807772
Source note	uspto-grants-2004_09