Acetone → 2-[[2-(2-Benzo[b]thiophen-5-ylethoxy)ethyl](methyl)amino]-1-propanol oxalate

Participants

Reaction Steps

In 0.9 mL of ethyl acetate is dissolved 0.18 g of 2-{[2-(2-benzo[b]thiophen-5-ylethoxy)ethyl]-(methyl)amino}-1-propanol, to which is added 2 mL of a solution of 0.055 g of oxalic acid in ethyl acetate. Then, 1 ml of acetone is added, and the resulting mixture is stirred at ambient temperature for 3.5 hours. The deposited crystal is collected by filtration, washed with ethyl acetate and dried to obtain 0.23 g of 2-[[2-(2-benzo[b]thiophen-5-ylethoxy)ethyl](methyl)amino]-1-propanol oxalate.

Provenance & Evidence