HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-3-nitropyridine → 3-Nitro-2-phenoxypyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-3-nitropyridine | HCID 79613 | — |
| Reactant | Phenolate Sodium | HCID 4445035 | — |
| Product | 3-Nitro-2-phenoxypyridine | HCID 901896 | — |
Reaction Steps
In step (3) of Reaction Scheme I, a 2-chloro-3-nitropyridine of Formula XII is reacted with sodium phenoxide to provide a 3-nitro-2-phenoxypyridine of Formula XIII. Phenol is reacted with sodium hydride in a suitable solvent such as tetrahydrofuran to form the phenoxide. The phenoxide is then reacted at an elevated temperature with a compound of Formula XII.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06797718B2 |
| Source dataset | uspto-grants-2004_09 |
| ORD ID | ord-8eb13454e22e42afaf3d94dc4bf3a467 |
| Source note | uspto-grants-2004_09 |