HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl isobutyrylacetate → HCID 69052716, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl isobutyrylacetate | HCID 81583 | — |
| Reactant | Sodium Acetate | HCID 517045 | — |
| Reactant | Ethanone, 2-amino-1-phenyl-, hydrochloride (1:1) | HCID 2723597 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 69052716 | HCID 69052716 | 93% |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
A mixture of 2-aminoacetophenone hydrochloride (1 equiv.), ethyl isobutyrylacetate (1.2 equiv.) and sodium acetate (2.4 equiv.) in H2O was stirred at 100° C. for 18 hours and then cooled to room temperature. The aqueous layer was decanted off and the oil was dissolved in ethyl acetate. It was then washed with water and brine and then dried to give (93%) of 2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid ethyl ester as a red brown oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06797725B2 |
| Source dataset | uspto-grants-2004_09 |
| ORD ID | ord-3b5dfa553842483c8451239085d5cab0 |
| Source note | uspto-grants-2004_09 |