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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1008176Generated: October 27, 2026

6-Phenyl-1,3-dihydro-indol-2-one → 2,4-Dimethyl-5-(2-oxo-6-phenyl-1,2-dihydroindol-3-ylidenemethyl)-1H-pyrrole-3-carboxylic acid (3-imidazol-1-ylpropyl)amide

https://huagongshe.com/reaction/1008176

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-Phenyl-1,3-dihydro-indol-2-oneHCID 10536384—
Reactant5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (3-imidazol-1-ylpropyl)amideHCID 86586208—
Product2,4-Dimethyl-5-(2-oxo-6-phenyl-1,2-dihydroindol-3-ylidenemethyl)-1H-pyrrole-3-carboxylic acid (3-imidazol-1-ylpropyl)amideHCID 6728171943%

Reaction Steps

6-Phenyl-1,3-dihydroindol-2-one (8 mg, 0.04 mmol) was condensed with 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (3-imidazol-1-ylpropyl)amide (10 mg) to give 7.3 mg (43%) of the title compound as an orange solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06797725B2
Source datasetuspto-grants-2004_09
ORD IDord-ede53b58180e471a82fc753ee3c8e6c0
Source noteuspto-grants-2004_09