HRID1008204

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID20761729

未命名化合物

HCID69052510

2-Oxo-2,3-dihydro-1H-indole-5-sulfonic acid pyridin-3-ylamide

C13H11N3O3S

PRODUCTS

生成物

结构：Cc1[nH]c(C=C2C(=O)Nc3ccc(S(=O)(=O)Nc4cccnc4)cc32)c(C)c1C(=O)NCCN1CCCC1

HCID67281969

2,4-Dimethyl-5-(2-oxo-5-(pyridin-3-ylsulfamoyl)-1,2-dihydroindol-3-ylidenemethyl]-1H-pyrrole-3-carboxylic acid (2-pyrrolidin-1-ylethyl)amide

C27H30N6O4S

收率 74%

PROCEDURE

实验过程

2-Oxo-2,3-dihydro-1H-indole-5-sulfonic acid pyridin-3-ylamide (110 mg, 0.38 mmol) was condensed with 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-pyrrolidin-1-ylethyl)amide (100 mg) to give 150 mg (74%) of the title compound as an orange solid.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b44ae349d8944e70b84dfa22658ce6b5
来源数据集: uspto-grants-2004_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06797725B2
来源说明: uspto-grants-2004_09

反应 SMILES

[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([NH:7][S:8]([C:11]2[CH:12]=[C:13]3[C:17](=[CH:18][CH:19]=2)[NH:16][C:15](=[O:20])[CH2:14]3)(=[O:10])=[O:9])[CH:2]=1.[N:21]1([CH2:26][CH2:27][NH:28][C:29]([C:31]2[C:35]([CH3:36])=[C:34]([CH:37]=O)[NH:33][C:32]=2[CH3:39])=[O:30])[CH2:25][CH2:24][CH2:23][CH2:22]1>>[N:21]1([CH2:26][CH2:27][NH:28][C:29]([C:31]2[C:35]([CH3:36])=[C:34]([CH:37]=[C:14]3[C:13]4[C:17](=[CH:18][CH:19]=[C:11]([S:8](=[O:10])(=[O:9])[NH:7][C:3]5[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=5)[CH:12]=4)[NH:16][C:15]3=[O:20])[NH:33][C:32]=2[CH3:39])=[O:30])[CH2:25][CH2:24][CH2:23][CH2:22]1