Sodium Dithionite → 8-Aminoguanine

HRID 1008230Notes

Reaction equation

HRID 1008230 reaction equation
[N+:1]([C:4]1[NH:12][C:11]2[C:10](=[O:13])[NH:9][C:8]([NH2:14])=[N:7][C:6]=2[N:5]=1)([O-])=O.S(S([O-])=O)([O-])=O.[Na+].[Na+]>Cl.[Zn]>[NH2:1][C:4]1[NH:12][C:11]2[C:10](=[O:13])[NH:9][C:8]([NH2:14])=[N:7][C:6]=2[N:5]=1

Participants

4

Reactant 2

HCID 24489Sodium DithioniteHCID 1354820678-Nitroguanine2×

Product 1

HCID 1354218878-Aminoguanine

Reagents, catalysts & solvents 1

HCID 57459388HCID 57459388, compoundCatalyst

Procedure

The product of this reaction was analyzed in comparison with data on the published spectra of 8-nitroguanine. The reaction product was reduced by zinc-HCl or sodium hydrosulfite. Under these conditions, 8-nitroguanine is reduced to form 8-aminoguanine. This reduced product was compared by HPLC and spectral analysis with 8-aminoguanine synthesized by acid hydrolysis of commercially available 8-aminoguanosine.

Sources & evidence

ORD record
ord-6213e95981df4f32a3e85f9190658eb0
Source dataset
uspto-grants-2004_09
Patent number
US06797822B1

Reaction notes

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