HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidine → HCID 66675422, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | Pyrrole-2-carboxaldehyde | HCID 13854 | — |
| Reactant | 6-bromo-2,3-dihydro-1H-indol-2-one | HCID 2773289 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 66675422 | HCID 66675422 | 48% |
Reaction Steps
A solution of 6-bromo-1,3-dihydro-2H-indol-2-one (100 mg, 0.47 mmol), 1H-pyrrole-2-carbaldehyde (49.2 mg, 0.52 mmol), and piperidine (0.02 mL, 0.2 mmol) in methanol (3 mL) was stirred at 65° C. for 2 hours, cooled to room temperature, and filtered. The filter cake was washed with hexanes to provide the desired product (65 mg, 48%). MS (DCI/NH3) m/z 290 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06797825B2 |
| Source dataset | uspto-grants-2004_09 |
| ORD ID | ord-7f09e85bbaa241508aecacb30fb32c31 |
| Source note | uspto-grants-2004_09 |