(2S,3R)-3-(2-butenyl)-2-hydroxysuccinic dimethyl ester → (2S,3R)-3-(n-butyl)-2-hydroxysuccinic dimethyl ester

Participants

Reaction Steps

To (2S,3R)-3-(2-butenyl)-2-hydroxysuccinic dimethyl ester F-2 (2.5 g) in ethyl acetate (50 mL) was added 10% Pd/C (0.25 g) and the reaction stirred under a hydrogen atmosphere for 20 h. The suspension was filtered through a pad of Celite, washed with EtOAc (3×) and then concentrated in vacuo to afford (2S,3R)-3-(n-butyl)-2-hydroxysuccinic dimethyl ester F-3.

Provenance & Evidence