Methanol → N-{2-Chloro-4-[(6,7-dimethoxy-4-quinolyl) oxy]phenyl}-N'-(2-methoxyphenyl)urea

Participants

Reaction Conditions

Reaction Steps

2-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]aniline (100 mg) was dissolved in chloroform(10 ml), and 2-methoxyphenyl isocyanate (54 mg) was added to the solution. The mixture was stirred at 600° C. overnight. Methanol was added to the reaction solution, and the solvent was removed by distillation under the reduced pressure. The residue was purified by chromatography on silica gel by development with chloroform/acetone (6/4) to give 111 mg (yield 77%) of the title compound.

Provenance & Evidence