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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1008364Generated: October 30, 2026

Diethyl Ether → HCID 69352948, compound

https://huagongshe.com/reaction/1008364

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDiethyl EtherHCID 3283—
Reactant2,4-Difluorophenyl isocyanateHCID 593258—
Reactant4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2,3-dimethylanilineHCID 21890439—
SolventChloroformHCID 6212—
ProductHCID 69352948HCID 6935294870%

Reaction Steps

4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2,3-dimethyl-aniline (710 mg) was dissolved in chloroform (7 ml), and 2,4-difluorophenyl isocyanate (310 μl) was then added to the solution. The mixture was heated under reflux for one hr, and a large amount of ether was added to the reaction solution. The resultant precipitate was collected by suction filtration to give 735 mg (yield 70%) of the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06797823B1
Source datasetuspto-grants-2004_09
ORD IDord-937f4bca62984b35b814bd0e732b516b
Source noteuspto-grants-2004_09